Table 4. Predictors of individual cardiovascular risk factors (CVRF) and CVRF cluster in multivariate analysis.
Elevated blood pressure | Elevated glucose | Low HDL | CVRF cluster* | |||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Age at TBI | 1.0 (0.9, 1.2) | 0.64 | 0.8 (0.8, 0.9) | <0.001 | 1.1 (0.98,1.3) | 0.09 | 0.9 (0.8, 1.0) | 0.16 |
Sex | ||||||||
Male | ||||||||
Female | ||||||||
Race | ||||||||
White, non-Hispanic | ||||||||
Other | ||||||||
Cranial RT | 0.002 | |||||||
No | Reference | |||||||
Yes | 4.0 (1.7, 9.6) | |||||||
Anthracycline dose (mg/m2) | 0.04 | |||||||
≤ 300 mg/m2 | Reference | |||||||
>300 mg/m2 | 2.0 (1.04, 3.9) | |||||||
Glucocorticoids | ||||||||
No | ||||||||
Yes | ||||||||
HCT type | ||||||||
T-cell depleted | ||||||||
Unmodified | ||||||||
aGVHD grade | 0.007 | 0.008 | ||||||
Grade 0-1 | Reference | Reference | ||||||
Grade 2-4 | 4.3 (1.5,12.3) | 4.2 (1.5, 12.2) | ||||||
GH deficiency** | 0.02 | 0.002 | ||||||
No | Reference | Reference | ||||||
Yes | 3.9 (1.3,12.3) | 8.6 (2.1, 34.4) |
Note: All analyses are stratified by treatment year ≤ 2000 vs > 2000 with time zero defined as age at TBI + 1 year; multivariate models constructed via forward selection with age at TBI in the initial model and considering all univariate covariates with p<0.1 as candidate predictors; full results for each model are shown. No significant predictors at 0.05 level for obesity or hypertriglyceridemia, thus omitted from the table above
CVRF cluster defined as having 3 or more of the following CVRF: obesity, elevated glucose, elevated blood pressure, low HDL, high triglycerides
Time dependent covariate;
Abbreviations: TBI, indicates total body irradiation; HCT, hematopoietic cell transplantation; GVHD, graft-versus-host disease; GH, growth hormone; HDL, high density lipoprotein