Table 4. Predictors of individual cardiovascular risk factors (CVRF) and CVRF cluster in multivariate analysis.

	Elevated blood pressure		Elevated glucose		Low HDL	CVRF cluster*
	HR (95% CI)	P	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age at TBI	1.0 (0.9, 1.2)	0.64	0.8 (0.8, 0.9)	<0.001	1.1 (0.98,1.3)	0.09	0.9 (0.8, 1.0)	0.16
Sex
Male
Female
Race
White, non-Hispanic
Other
Cranial RT								0.002
No							Reference
Yes							4.0 (1.7, 9.6)
Anthracycline dose (mg/m2)						0.04
≤ 300 mg/m2					Reference
>300 mg/m2					2.0 (1.04, 3.9)
Glucocorticoids
No
Yes
HCT type
T-cell depleted
Unmodified
aGVHD grade		0.007						0.008
Grade 0-1	Reference						Reference
Grade 2-4	4.3 (1.5,12.3)						4.2 (1.5, 12.2)
GH deficiency**		0.02						0.002
No	Reference						Reference
Yes	3.9 (1.3,12.3)						8.6 (2.1, 34.4)

Note: All analyses are stratified by treatment year ≤ 2000 vs > 2000 with time zero defined as age at TBI + 1 year; multivariate models constructed via forward selection with age at TBI in the initial model and considering all univariate covariates with p<0.1 as candidate predictors; full results for each model are shown. No significant predictors at 0.05 level for obesity or hypertriglyceridemia, thus omitted from the table above

^*CVRF cluster defined as having 3 or more of the following CVRF: obesity, elevated glucose, elevated blood pressure, low HDL, high triglycerides

^**Time dependent covariate;

Abbreviations: TBI, indicates total body irradiation; HCT, hematopoietic cell transplantation; GVHD, graft-versus-host disease; GH, growth hormone; HDL, high density lipoprotein