Table 2. Comparison of organ involvement in three large case series.
| Organ | Chen
et al.
7,
percentage of 200 cases a |
Fernandez-
Codina et al. 3, percentage of 55 cases b |
Inoue
et al.
2,
percentage of 235 cases c |
|---|---|---|---|
| Lymph nodes | 56.5% | ||
| Adenopathic | 2% | ||
| Salivary glands | 16% | 34% | |
| Submandibular
gland |
51.0% | ||
| Parotid gland | 24.0% | ||
| Pancreas | 38.5% | 16% | 60% c |
| Lung | 32.0% d | 9% | 13% |
| Pleura | 4% | ||
| Sinus | 21.5% | ||
| Maxillary | 15% | ||
| Bile ducts/biliary | 19.0% | 4% | 13% |
| Retroperitoneal
tissue |
18.0% | 27% | 4% |
| Prostate | 13.0% | 0% | |
| Kidney | 10.0% | 7% | 23% |
| Artery | 7.0% | 0% | 4% |
| Gallbladder | 5.5% | 5% | |
| Skin | 5.5% | 0% | |
| Inflammatory
pseudotumor |
5.0% | ||
| Liver | 3.0% | 0% | |
| Orbit | 4% | ||
| Orbitary
pseudotumor |
22% | ||
| Extraocular
muscles |
2% | ||
| Lacrimal gland | 42.0% | 15% | 23% |
| Aorta | 9% | 20% |
Chen et al. had predominantly Chinese cases 7, Fernandez-Codina et al. 3 analyzed patients from a Spanish registry 6, and Inoue et al. studied a Japanese cohort 2. aChen et al. included those who fulfilled 2011 diagnostic criteria for definite, probable, or possible IgG4-related disease 7. bFernandez-Codina et al. used 2012 international diagnostic consensus on IgG4-related disease for their inclusion 6. Fernandez-Codina et al. also reported 2% involvement of the thyroid, breast, pericardium, or mediastinum; 7% involvement of the mesentery; 4% involvement of the pachymeninges; and 0% involvement of the hypophysis. cInoue et al. included patients with a diagnosis of type I autoimmune pancreatitis as well as those with IgG4-related disease on pathology, which is possibly what accounts for a greater number of patients with pancreatic involvement 2. Inoue et al. reported 5% involvement of the paravertebra and 3% other sites. dIn Chen et al., this includes parenchyma, airway, and pleura.