Fig. 3.

Effects of 4MM and MeCa on core body temperature. Mice were treated with (A) 4MM (4 × 2.5, 5, 10, 20, or 40 mg/kg), (C) MeCa (4 × 20, 40, or 80 mg/kg), or saline vehicle every 2 hours for a total of four injections. Body temperature was monitored beginning 40 minutes prior to the first injection via telemetry, and was measured at 20-minute intervals for the duration of the experiment. Data are mean temperature values with S.E.M. (<5% of the mean for each group) omitted for clarity (4MM: control, n = 4; 2.5–20 mg/kg, n = 4; 40 mg/kg, n = 5; for MeCa: control, n = 9; 20 mg/kg, n = 6; 40 mg/kg, n = 10; 80 mg/kg, n = 8). This experiment was performed once for 4MM, and repeated twice with differing doses for MeCa. The mean difference from control animals over the course of the entire experiment for each dose is shown in (B) and (D) ± S.E.M. Two-way repeated-measures ANOVA, ****P < 0.0001 compared with controls, with Bonferroni’s post-hoc test.