Fig. 4.

Effects of 4MM and MeCa on locomotor behavior. Mice were treated with 4MM (4 × 2.5, 5, 10, 20, or 40 mg/kg), MeCa (4 × 20, 40, or 80 mg/kg), or saline vehicle every 2 hours for a total of four injections. Horizontal activity (A), movement time (B), and stereotypy time (C) were monitored for 60 minutes following each injection. Data are mean values ± S.E.M. (4MM: control, n = 10; 2.5 mg/kg, n = 4; 5–40 mg/kg, n = 5; for MeCa: all groups: n = 4). This experiment was performed twice for 4MM and once for MeCa with differing doses, though owing to equipment size constraints, each experiment was performed over consecutive days. One-way ANOVA, *P < 0.05 **P < 0.01 ****P < 0.0001 compared with controls, with Bonferroni’s post-hoc test.