Table 1. mPFC pyramidal neuron response to 5-HT_1A agonists.

Whole cell recordings from mPFC cells showing percentage of cells that show a response to the bath perfused drug. A smaller proportion of Hetero-KO mPFC pyramidal cells responds to 5-CT compared to controls (Control: 9/11;Hetero-KO: 3/10)(Fisher’s: p<0.05; n=10–11/group). No changes were observed in the percentage of non-pyramidal cells. (Control: 3/7;Hetero-KO: 4/9)(Fisher’s: p=1.0)(n=7–9/group). All pyramidal cells respond robustly to Baclofen (Control: 4/4;Hetero-KO: 4/4)(Fisher’s: p=1.0; n=4/group).

Transgenic	Pyramidal 5-CT	Non-Pyramidal 5-CT	Pyramidal Baclofen
Control	82%	43%	100%
Hetero-KO	30%*	44%	100%

^*p≤0.05,

^**p<0.01.

Related to Figure 1.See also Figure S1.