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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: J Am Chem Soc. 2017 Feb 7;139(6):2464–2467. doi: 10.1021/jacs.6b12731

Figure 2.

Figure 2

Extracellular stability and transporter recognition of modified and unmodified unnatural triphosphates. (A) β,γ-CF2 modification stabilizes the unnatural triphosphates to degradation by secreted phosphatases. (B) The β,γ-CF2 modified unnatural triphosphates are still recognized by the SSO’s PtNTT2 transporter as detected by the inhibition of [α-32P]ATP uptake (see text and Supporting Information for details).