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. 2017 Feb 20;10:1059–1069. doi: 10.2147/OTT.S124012

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© 2017 Yi et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Tbx2 regulates mitochondrial fission/fusion and related proteins.

Notes: (A) Mitochondrial morphology was evaluated by confocal microscope using MitoTracker Green staining. Mitochondrial dynamics were prone to fission after Tbx2 overexpression in A172 cells. Tbx2 depletion led to mitochondrial fusion in U251 cells. (B) Tbx2 overexpression upregulated mean mtDNA content in A172 cells with Tbx2 plasmid. In contrast, Tbx2 depletion decreased mtDNA content in U251 cells. (C) Tbx2 overexpression upregulated cyclin D1, MMP9, p-Drp1, and MMP2 and downregulated p21 in A172 cell line. Tbx2 depletion downregulated cyclin D1, MMP9, p-Drp1, and MMP2 and upregulated p21 in U251 cell line. *P<0.05.

Abbreviation: mtDNA, mitochondrial DNA.