Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 20;10:1059–1069. doi: 10.2147/OTT.S124012

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Yi et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Tbx2 alleviated TMZ-induced apoptosis in GBM cell lines.

Notes: (A) Annexin V/PI staining and flow cytometry analysis showed that Tbx2 downregulated apoptosis rate induced by TMZ treatment in A172 cells. Tbx2 siRNA upregulated apoptosis induced by TMZ in U251 cells. (B) Tbx2 overexpression upregulated Bcl-2 and caspase 3 and downregulated cleaved caspase 3 and cytochrome C in A172 cell line. Tbx2 depletion downregulated Bcl-2 and caspase 3 and upregulated cleaved caspase 3 and cytochrome C in U251 cell line. *P<0.05.

Abbreviations: GBM, glioblastoma multiform; PI, propidium iodide; TMZ, temozolomide.