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. 2017 Mar;61:236–243. doi: 10.1016/j.bbi.2016.12.007

Fig. 3.

Fig. 3

LPS-induced anorexia is attenuated in mice given indomethacin i.c.v. but remain unaffected in mice lacking COX-2 in both brain endothelial and neural cells. A. Food intake in response to i.p. injection of LPS and i.c.v. injection of indomethacin (n = 3, vehicle + NaCl, vehicle + LPS, indo + NaCl; n = 4, indo + LPS; 2-way ANOVA, pre-treatment × treatment F (1, 9) = 10.28, P = 0.0107). B. Mice lacking COX-2 in brain endothelial and neural cells (Cox2ΔbEnd ± Nes) showed intact anorexia (D; n = 6, Cox2ΔbEnd + Nes-LPS; n = 8, Cox2ΔbEnd + Nes-NaCl; n = 11, WT-LPS; n = 9, WT-NaCl; 2-way ANOVA, treatment F (3, 33) = 13.94, P < 0.001).