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. 2017 Feb 13;12:1127–1141. doi: 10.2147/IJN.S123290

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© 2017 Tian et al. This work is published and licensed by Dove Medical Press Limited

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The in vivo pancreas distribution of DiR-loaded M-Gd-NL.

Notes: After the mild or severe AP SD rat models were established, the rats were treated with M-DiR-NL. M-DiR-NL was injected intravenously as a single dose (500 μg DiR/kg) via tail vein. The rats were anesthetized by inhalation. Four hours after injection, the rats were euthanized and the excised pancreas was imaged with IVIS^® Lumina II Imaging System and recorded by a built-in CCD camera. (A) A representative excised pancreas was shown. (B) Quantitative fluorescence analysis of excised pancreases. All comparisons were performed between the two groups by one-way analysis of variance with Newman–Keuls posttest. Data are expressed as mean ± standard deviation (n=3). **P<0.01; ***P<0.001.

Abbreviations: AP, acute pancreatitis; DiR, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide; M-DiR-NL, mannosylated DiR-loaded liposomes; M-Gd-NL, gadolinium-diethylenetriaminepentaacetic-loaded mannosylated liposomes; SD, Sprague Dawley.