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. 2017 Feb 17;12:1353–1368. doi: 10.2147/IJN.S126865

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© 2017 Chu et al. This work is published and licensed by Dove Medical Press Limited

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HPLC results for iRGD or TAT coupling to Mal–PEG–PLGA.

Notes: (A) Before the coupling step, free iRGD in the mixture of Mal–PEG–PLGA and iRGD showed a peak with a retention time at ~10.8 min. (B) After the coupling step, free iRGD in the mixture of Mal–PEG–PLGA and iRGD was incorporated onto the Mal–PEG–PLGA and the peak for iRGD was not obvious. (C) Before the coupling step, free TAT in the mixture of Mal–PEG–PLGA and TAT showed a peak with a retention time at ~20.08 min. (D) After the coupling step, free TAT in the mixture of Mal–PEG–PLGA and TAT was incorporated onto the Mal–PEG–PLGA and the peak for TAT was not obvious.

Abbreviations: HPLC, high-performance liquid chromatography; iRGD, internalizing arginine-glycine-aspartic acid; Mal–PEG–PLGA, maleimide-poly(ethylene glycol)-poly(lactic-co-glycolic acid); TAT, transactivated transcription.