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. 2017 Feb 17;12:1353–1368. doi: 10.2147/IJN.S126865

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© 2017 Chu et al. This work is published and licensed by Dove Medical Press Limited

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Cellular uptake images for different NPs after treating HUVECs at 1, 3, and 6 h.

Notes: The blue fluorescence and the red fluorescence belong to Hoechst 33342 and NPs labeled with Nile red, respectively. mPEG–PLGA-Nile red-NP, mPEG–PLGA NPs labeled with Nile red; iRGD-Nile red-NP, iRGD-modified NPs labeled with Nile red; TAT-Nile red-NP, TAT-modified NPs labeled with Nile red; iRGD–TAT-Nile red-NP, iRGD and TAT dual-modified NPs labeled with Nile red.

Abbreviations: HUVECs, human umbilical vein endothelial cells; iRGD, internalizing arginine-glycine-aspartic acid; mPEG, methoxy-poly(ethylene glycol); NP, nanoparticle; PLGA, poly(lactic-co-glycolic acid); TAT, transactivated transcription.