Table 4.

Characterization of NPs

Groups	Particle size (nm)	PDI	Zeta potential (mV)
mPEG–PLGA-Nile red-NP	53.4±2.4	0.128±0.011	−18.84±0.57
iRGD-Nile red-NP	60.1±2.8	0.106±0.052	−12.63±0.75
TAT-Nile red-NP	62.7±1.5	0.157±0.039	−10.86±0.39
iRGD–TAT-Nile red-NP	67.0±1.7	0.163±0.017	−6.63±0.43

Notes: Values represent the mean ± SD (n=3). mPEG–PLGA-Nile red-NP, mPEG–PLGA NPs labeled with Nile red; iRGD-Nile red-NP, iRGD-modified NPs labeled with Nile red; TAT-Nile red-NP, TAT-modified NPs labeled with Nile red; iRGD–TAT-Nile red-NP, iRGD and TAT dual-modified NPs labeled with Nile red.

Abbreviations: iRGD, internalizing arginine-glycine-aspartic acid; mPEG, methoxy-poly(ethylene glycol); NP, nanoparticle; PDI, polydispersity index; PLGA, poly(lactic-co-glycolic acid); SD, standard deviation; TAT, transactivated transcription.