Table 5.

Characterization of NPs with different densities of iRGD–PEG–PLGA

Groups	Particle size (nm)	PDI	Zeta potential (mV)
5% iRGD–TAT-Nile red-NP	62.4±1.6	0.136±0.032	−13.57±0.46
20% iRGD–TAT-Nile red-NP	67.0±1.7	0.163±0.017	−6.63±0.43
40% iRGD–TAT-Nile red-NP	192.9±5.7	0.389±0.073	−3.63±0.43

Notes: Values represent the mean ± SD (n=3). 5% iRGD–TAT-Nile red-NP, iRGD and TAT dual-modified NPs labeled with Nile red with 5% iRGD–PEG–PLGA; 20% iRGD–TAT-Nile red-NP, iRGD and TAT dual-modified NPs labeled with Nile red with 20% iRGD–PEG–PLGA; 40% iRGD–TAT-Nile red-NP, iRGD and TAT dual-modified NPs labeled with Nile red with 40% iRGD–PEG–PLGA.

Abbreviations: iRGD, internalizing arginine-glycine-aspartic acid; NP, nanoparticle; PEG, poly(ethylene glycol); PDI, polydispersity index; PLGA, poly(lactic-co-glycolic acid); SD, standard deviation; TAT, transactivated transcription.