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. 2017 Feb 24;12(2):e0172048. doi: 10.1371/journal.pone.0172048

Fig 3. Cleaved caspase 3 (CC3) expression increases in intermediate grade cancers and occurs early after ADT.

Fig 3

CC3 immunohistochemistry was performed on neoadjuvant ADT and control prostate tissues and then quantitated using the automated imaging analyzer VECTRA. Gleason scoring was performed on pretreatment biopsies. (A) Cell nuclear and cytoplasmic levels of CC3 demonstrate increased expression in ADT treated PCa tissues and increased levels in Gleason score 6 and 7 (B) compared to untreated controls. (C) CC3 expression is shown according to duration of neoadjuvant ADT treatment and compared to untreated controls. Significant increases in CC3 levels were seen within 1-5mo after ADT initiation. *p<0.05; mean±SE.