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. 2017 Feb 24;12(2):e0172627. doi: 10.1371/journal.pone.0172627

Fig 12. Cellular changes in spleens occurring in BALB/c and C57BL/6 mice after aerosol exposure to B. pseudomallei K96243.

Fig 12

Spleen homogenates were prepared from infected (A) BALB/c and (B) C57BL/6 mice over time, and the percent of each cell type examined was determined. After 22 days there were no BALB/c mice survivors. For each mouse strain N = 5 at each time point. The fold-change for each cell type was determined by dividing the percent of the cell type at each time point (S6 Table) by the percent of the cell type present in normal, naïve mice, where N = 10 for BALB/c and N = 4 for C57BL/6 mice. Significant changes in % cell type (S6 Table) are shown above the inflammatory cells (macrophages/monocytes, NK cells, and granulocytes) only because they showed the most predominate changes through out the study. Significant levels compared to the naïve, control mice: † P < 0.05; ¶ P < 0.01; § P ≤ 0.001.