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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Curr Opin Allergy Clin Immunol. 2016 Oct;16(5):441–450. doi: 10.1097/ACI.0000000000000305

Table 2.

Current descriptions of anaphylaxis in the literature

EAACI [15] WAO [16] AAAAI/ACAAI [17] ASCIA [18] NIAID [19]
A severe life-threatening generalized or systemic hypersensitivity reaction.

An acute, potentially fatal, multi-organ system, allergic reaction.
A serious life-threatening generalized or systemic hypersensitivity reaction.

A serious allergic reaction that is rapid in onset and might cause death
An acute life-threatening systemic reaction with varied mechanisms, clinical presentations, and severity that results from the sudden release of mediators from mast cells and basophils. Anaphylaxis is a serious, rapid-onset, allergic reaction that may cause death.

Severe anaphylaxis is characterised by life-threatening upper airway obstruction, bronchospasm and/or hypotension.
Anaphylaxis is a serious allergic reaction that involves more than one organ system (for example, skin, respiratory tract, and/or gastrointestinal tract). It can begin very rapidly, and symptoms may be severe or life-threatening.