Table 1e. Differentially expressed mRNA important for regulating proliferative control by altering genes for proliferative enzymes and miscellaneous proliferative proteins.

PROLIFERATIVE CONTROL
Gene	Function	V vs PF*	P3 vs PF	V vs P3
Enzymatic Activity
#ADAMTS1	Metalloproteinase – promotes proliferation	+22.01	+3.63	+5.66
BRCA1	Tumor suppressor – inhibits proliferation		−5.78
#DUSP1	Phosphatase – inhibits proliferation	−3.61		−2.31
DUSP4	Phosphatase – inhibits proliferation	−3.07	−2.43
DUSP10	Phosphatase – inhibits proliferation			−2.20
^#DYRK	Kinase – inhibits cellular proliferation		+2.75	−3.34
PDIA4	Protein disulfide isomerase – IGFR recycler			+2.73
PPP6C	Phosphatase – restricts G1/S progression		+2.57
^PRUNE	Phosphodiesterase – promotes proliferation		+3.32	−2.66
PTPRK	Negative regulator of EGFR		−7.89
TENC1	Negative regulator of Akt		+2.45
#TIMP2	Inhibits cellular proliferation	−2.68
Other
#CAV1	Antiproliferative – downregulates Cyclin Da		+5.31	−2.95
CRLF3	Negative regulator of cell cycle progression		−3.10
EPB41L3	Suppresses proliferation	−6.32	−3.20
FOSL1	Promotes cellular proliferation	−5.21	−4.69
Gpnmb	Inhibits cellular proliferation		−14.52	+3.32
#NPM1	Promotes cellular proliferation		−2.31
PHF10	Chromatin remodeler – promotes proliferation	+2.13	+2.99
SDC1	Promotes proliferation	−2.43	−2.33
UBN1	Chromatin remodeler – promotes senescence		+2.10

Gene name, function and fold change for each gene are listed; downregulated genes indicated by negative numbers, upregulated genes indicated by positive numbers.

^*Comparisons are made between empty vector and PAX3-FOXO1 (V vs. PF), PAX3 and PAX3-FOXO1 (P3 vs. PF) or empty vector and PAX3 (V vs. P3),

^{^}indicates genes demonstrated to have PAX3-FOXO1 binding sites present in their proximal promoter [29]

^#indicates genes that demonstrate similar trends in gene expression changes in human tumor samples [30–33].