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. 2016 Feb 19;7(39):62925–62938. doi: 10.18632/oncotarget.7497

Figure 1. FXYD2 is highly expressed in ovarian clear cell cancer.

Figure 1

A. and B. the mRNA expression levels of FXYD2 were compared in clinical ovarian cancer specimens from our Affymetrix GeneChip HG-U133_Plus_2 analysis (GSE44104) and three GEO databases. All of the specimen groups were compared to clear cell ovarian cancer group using one-way ANOVA followed by Bonferroni multiple comparisons test. C. representative images of immunohistochemical analysis of FXYD2 in ovarian cancer sections. Consecutive sections were stained with hematoxylin and eosin (H&E) to define representative tumor regions. Magnification ×200. Scale bar, 200 μm. Comparison of FXYD2 mRNA expressions in clinical ovarian cancer specimens (D. clear cell, n = 46; serous, n = 28) and (E. early, stage 1 and 2, n=22; advanced, stage 3 and 4, n=24). The FXYD2 expression levels were determined by qRT-PCR and normalized to GAPDH expression. All of the qRT-PCR data presented is from three independent experiments that were analyzed using an unpaired t test. F. Kaplan-Meier survival plots for patients with ovarian clear cell carcinoma (n = 46) according to FXYD2 mRNA expression. The FXYD2 mRNA levels were measured by qRT-PCR and normalized to the GAPDH expression. The median value was used to divide patients into high (n = 23) and low (n = 23) FXYD2 expression groups. Statistical comparison of Kaplan-Meier curve was analyzed by the log-rank test.