Figure 5. Cardiac glycoside significantly suppresses tumor growth and improves the survival of OCCC-bearing animals.

A. NOD/SCID mice were subcutaneously injected with 2.5×10⁶ OCCC (TOV-21G) or non-OCCC (SKOV3) cells (n = 7 mice per group). One week after inoculation, mice were daily intraperitoneally injected with PBS or digoxin for 28 days. Tumor volume was measured every 7 days. P values were determined using an unpaired t test. B. Kaplan–Meier survival curve of xenograft mice treated with PBS or digoxin. NOD/SCID mice were intraperitoneally injected with 5×10⁵ OCCC (IGROV-1) or non-OCCC (SKOV3) cells. Three weeks after inoculation, mice were intraperitoneally injected daily with PBS or digoxin. P values were determined using a log-rank test.