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. 2016 Aug 19;7(39):63003–63019. doi: 10.18632/oncotarget.11416

Figure 6. Elevated levels of SLFN11 contribute to the sensitivity of Ewing sarcoma cells to inhibition of RNR.

Figure 6

A. Western blot showing levels of SLFN11 in Ewing sarcoma cells and non-Ewing sarcoma cell lines. B. Western blot showing levels of SLFN11 and RRM2 after transfection of cells with siRNAs that target SLFN11, RRM2 or both SLFN11 and RRM2. C. Concurrent knockdown of RRM2 and SLFN11 with siRNA partially rescues the effects of RRM2 knockdown on Ewing sarcoma cell viability. D. Knockdown of SLFN11 with siRNA in Ewing sarcoma cells partially rescues cells from the toxicity of ciclopirox. ** P-value < 0.01; *** P-value < 0.001.