Figure 4. GDC-0941 does not affect radiation-induced DNA damage in immortalised thyroid cells.

Radiotherapy increased γH2AX expression to similar levels to that observed in thyroid carcinoma cell lines but had little effect under anoxia. GDC-0941 had little effect on radiation-induced DNA damage under normoxia or anoxia. Immortalised thyroid cells were treated and analysed as described in figure legend 3. Data represents the mean ± S.D. of 3 experimental repeats.