Figure 2. The mean level of nuclear (A, C) and cytoplasmic (B, D) RORα (A, B) and RORγ (C, D) in keratinocytes of normal skin and keratinocytes of skin surrounding melanocytic nevi and melanomas.

Statistically significant differences are denoted with P values as determined by Student's t-test and with asterisks by ANOVA (*P<0.05, **P<0.01 and ***P<0.001). Representative RORα (E-G) and RORγ (H-J) immunostaining of normal skin (E, H), skin surrounding melanocytic nevi (F, I) and skin surrounding melanomas (G, J different cases, separated with dashed line). Arrows indicate nuclear staining in melanomas, scale bars - 50μm.