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. 2016 Aug 23;7(39):63611–63628. doi: 10.18632/oncotarget.11553

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Copyright: © 2016 García-Heredia et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Overexpression of NumbL cDNA downregulates stem- and Notch-pathway related genes. (B) Type and percentage of each of the different clones observed for HeLa, T47D and AX cells upon overexpression of NumbL cDNA. Figure shows typical colonies (left) and the percentage of each type in all cases (right). (C) Tumorsphere assay for HeLa cells (2nd generation), T47D cells (1st generation), and AX low passaged sarcoma cells (1st generation) showing total number of tumorspheres. All experiments were repeated a minimum of three independent times in triplicate. All figures include Student's T test for statistical analysis of the data. * = p < 0.05; ** = p < 0.01; *** = p < 0.001.