Figure 11. Curcumin potentiates the antitumor activity of cisplatin against human bladder cancer cells in nude mice.

Animals bearing 253J-Bv cell xenografts were treated with curcumin (500 mg/kg) or cisplatin (5 mg/kg) alone or in combination. Animals were classified into four groups (n=10): the control group was treated with saline; group 1 was treated with cisplatin alone (5 mg/kg, i.p./weekly); group 2 was treated with curcumin alone (500 mg/kg, orally/thrice weekly); and group 3 was treated with the combination of curcumin (500 mg/kg, orally/thrice weekly) and cisplatin (5 mg/kg, i.p./weekly). A. Representative photomicrographs of 253J-Bv tumors from control, cisplatin, curcumin, or combination treated groups on the last day of the experiment. B, C. Tumor volumes and body weights were measured at indicated time intervals. Point, mean; bar, SEM. *p <0.05 compared with results of the control group was considered statistically significant.