Table 2. Results of meta-analysis for the association between LSP1 rs1817198 T > C polymorphism and breast cancer risk.
Variables | N (cases/controls) | Homozygous | Heterozygous | Recessive | Dominant | Allele | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC vs. TT | TC vs. TT | CC vs. (TC + TT) | (TC +CC) vs. TT | C vs. T | ||||||||||||
OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | OR (95% CI) | Phet | I2 (%) | ||
All | 12(50,525/54302) | 1.12 (1.02-1.24) | 0.032 | 49.3 | 1.12 (0.90-1.39) | <0.001 | 97.6 | 1.07 (0.91-1.25) | <0.001 | 82.1 | 1.13 (0.94-1.36) | <0.001 | 97.1 | 1.09 (1.00-1.19) | <0.001 | 91.6 |
Ethnicity | ||||||||||||||||
Caucasian | 6(11470/10331) | 1.21 (1.10-1.32) | 0.408 | 1.4 | 1.07 (1.01-1.13) | 0.812 | 0.0 | 1.16 (1.07-1.27) | 0.436 | 0.0 | 1.10 (1.04-1.16) | 0.686 | 0.0 | 1.09 (1.05-1.13) | 0.475 | 0.0 |
Asian | 3(7624/5743) | 1.17 (0.70-1.95) | 0.563 | 0.0 | 1.07 (0.90-1.26) | 0.324 | 0.0 | 1.14 (0.69-1.89) | 0.606 | 0.0 | 1.07 (0.89-1.28) | 0.277 | 15.4 | 1.09 (1.01-1.17) | 0.515 | 0.0 |
African | 1(742/658) | 0.45 (0.22-0.92) | - | - | 1.16 (0.92-1.47) | - | - | 0.43 (0.22-0.88) | - | - | 1.08 (0.86-1.35) | - | - | 0.98 (0.81-1.20) | - | - |
Mixed | 2(30689/37570) | 1.05 (0.94-1.17) | 0.082 | 67.0 | 1.29 (0.70-2.41) | <0.001 | 99.7 | 0.90 (0.72-1.13) | <0.001 | 93.1 | 1.26 (0.73-2.17) | <0.001 | 99.6 | 1.12 (0,85-1.46) | <0.001 | 99.1 |
Source of control | ||||||||||||||||
Nested | 3(38500/44177) | 1.08 (0.99-1.18) | 0.076 | 61.2 | 1.22 (0.79-1.88) | <0.001 | 99.5 | 0.97 (0.79-1.19) | <0.001 | 93.8 | 1.20 (0.83-1.74) | <0.001 | 99.4 | 1.10 (0.93-1.31) | <0.001 | 98.3 |
PB | 7(10406/8365) | 1.19 (0.88-1.63) | 0.036 | 57.9 | 1.06 (0.97-1.17) | 0.763 | 0.0 | 1.16 (0.86-1.56) | 0.040 | 57.1 | 1.09 (0.99-1.19) | 0.644 | 0.0 | 1.09 (1.03-1.15) | 0.429 | 0.0 |
HB | 2(1619/1760) | 1.13 (0.81-1.56) | 0.651 | 0.0 | 1.07 (0.91-1.25) | 0.332 | 0.0 | 1.12 (0.82-1.54) | 0.756 | 0.0 | 1.08 (0.92-1.26) | 0.345 | 0.0 | 1.07 (0.94-1.22) | 0.375 | 0.0 |
PB, population based; HB, hospital based.