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. 2016 Aug 31;7(39):63960–63967. doi: 10.18632/oncotarget.11741

Table 2. Results of meta-analysis for the association between LSP1 rs1817198 T > C polymorphism and breast cancer risk.

Variables N (cases/controls) Homozygous Heterozygous Recessive Dominant Allele
CC vs. TT TC vs. TT CC vs. (TC + TT) (TC +CC) vs. TT C vs. T
OR (95% CI) Phet I2 (%) OR (95% CI) Phet I2 (%) OR (95% CI) Phet I2 (%) OR (95% CI) Phet I2 (%) OR (95% CI) Phet I2 (%)
All 12(50,525/54302) 1.12 (1.02-1.24) 0.032 49.3 1.12 (0.90-1.39) <0.001 97.6 1.07 (0.91-1.25) <0.001 82.1 1.13 (0.94-1.36) <0.001 97.1 1.09 (1.00-1.19) <0.001 91.6
Ethnicity
Caucasian 6(11470/10331) 1.21 (1.10-1.32) 0.408 1.4 1.07 (1.01-1.13) 0.812 0.0 1.16 (1.07-1.27) 0.436 0.0 1.10 (1.04-1.16) 0.686 0.0 1.09 (1.05-1.13) 0.475 0.0
Asian 3(7624/5743) 1.17 (0.70-1.95) 0.563 0.0 1.07 (0.90-1.26) 0.324 0.0 1.14 (0.69-1.89) 0.606 0.0 1.07 (0.89-1.28) 0.277 15.4 1.09 (1.01-1.17) 0.515 0.0
African 1(742/658) 0.45 (0.22-0.92) - - 1.16 (0.92-1.47) - - 0.43 (0.22-0.88) - - 1.08 (0.86-1.35) - - 0.98 (0.81-1.20) - -
Mixed 2(30689/37570) 1.05 (0.94-1.17) 0.082 67.0 1.29 (0.70-2.41) <0.001 99.7 0.90 (0.72-1.13) <0.001 93.1 1.26 (0.73-2.17) <0.001 99.6 1.12 (0,85-1.46) <0.001 99.1
Source of control
Nested 3(38500/44177) 1.08 (0.99-1.18) 0.076 61.2 1.22 (0.79-1.88) <0.001 99.5 0.97 (0.79-1.19) <0.001 93.8 1.20 (0.83-1.74) <0.001 99.4 1.10 (0.93-1.31) <0.001 98.3
PB 7(10406/8365) 1.19 (0.88-1.63) 0.036 57.9 1.06 (0.97-1.17) 0.763 0.0 1.16 (0.86-1.56) 0.040 57.1 1.09 (0.99-1.19) 0.644 0.0 1.09 (1.03-1.15) 0.429 0.0
HB 2(1619/1760) 1.13 (0.81-1.56) 0.651 0.0 1.07 (0.91-1.25) 0.332 0.0 1.12 (0.82-1.54) 0.756 0.0 1.08 (0.92-1.26) 0.345 0.0 1.07 (0.94-1.22) 0.375 0.0

PB, population based; HB, hospital based.