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. 2016 Aug 31;7(39):64007–64020. doi: 10.18632/oncotarget.11746

Figure 4. Gata3 deficiency in p18 null mice induces B-cell lymphomas.

Figure 4

(A) Representative lymphomas developed in p18−/−;Gata3+/− mice. Note the multiple enlarged lymph nodes (black arrows) and typical enlarged spleen (white arrow). (B) Representative gross appearance of spleens from age-matched (12–14 months of age) WT, Gata3+/−, p18−/− and p18−/−;Gata3+/− mice. (C, D) Representative H&E (C) and immunofluorescence staining (D) of primary lymphomas developed in p18−/−;Gata3+/−mice. (E) Lymphoma-free survival of mice with different genotypes. p = 0.018 among four groups by Log-rank (Mantel-Cox) Test. (F) Representative p18−/−;Gata3+/− lymphomas infiltrated into multiple organs, determined by H&E staining.