Table 2. Association between methylation difference (%) and clinicopathological parameters.
| Parameters | NO. | Normal | Tumor | ΔMean | P |
|---|---|---|---|---|---|
| Gender | 0.66 | ||||
| Male | 111 | 61.4 | 65.7 | 4.3 | |
| Female | 10 | 70.6 | 72.7 | 2.1 | |
| Age | 0.53 | ||||
| <58 | 52 | 61.6 | 66.8 | 5.2 | |
| ≥58 | 69 | 62.6 | 66.0 | 3.4 | |
| Alcohol habit | 0.43 | ||||
| No | 99 | 59.8 | 65.1 | 5.3 | |
| Yes | 86 | 65.1 | 67.9 | 2.8 | |
| Smoking | 0.05 | ||||
| No | 41 | 59.1 | 67.4 | 8.3 | |
| Yes | 80 | 63.7 | 65.8 | 2.1 | |
| Nerve invasion | 0.63 | ||||
| No | 95 | 62.4 | 66.9 | 4.5 | |
| Yes | 26 | 61.2 | 64.2 | 3.0 | |
| Vessels invasion | 0.86 | ||||
| No | 102 | 62.5 | 66.5 | 4.0 | |
| Yes | 19 | 60.4 | 65.5 | 5.1 | |
| T stage | 0.88 | ||||
| T1-2 | 27 | 59.1 | 63.0 | 3.9 | |
| T3 | 94 | 63.0 | 67.3 | 4.3 | |
| N stage | |||||
| N0 | 57 | 57.6 | 65.1 | 7.5 | 0.04 |
| N1-3 | 64 | 66.1 | 67.5 | 1.4 | |
| TNM stage | 0.13 | ||||
| I-II | 61 | 58.6 | 65.1 | 6.5 | |
| III | 60 | 65.7 | 67.6 | 1.9 | |
| Differentiation | 0.46 | ||||
| Well | 13 | 65.8 | 64.9 | −0.9 | |
| Moderate | 68 | 61.1 | 66.5 | 5.4 | |
| Poor | 40 | 62.7 | 66.6 | 3.9 | |
| Lesion location | 0.15 | ||||
| Upper thoracic | 44 | 61.7 | 67.9 | 6.2 | |
| Middle thoracic | 46 | 63.6 | 64.1 | 0.5 | |
| Low thoracic | 31 | 60.5 | 67.4 | 6.9 |