Table 3. Multivariate Cox regression model.
Cox Model | HR | 95% CI | P |
---|---|---|---|
Ewings vs. Osteosarcoma | 1.2 | 0.6, 2.7 | 0.56 |
Chondrosarcoma vs. Osteosarcoma | 0.8 | 0.3, 2.2 | 0.7 |
Other tumor type vs. Osteosarcoma | 0.1 | 0.3, 0.6 | 0.0084 |
Sex: male vs. female | 2.2 | 1.1, 4.4 | 0.025 |
Body surface area: ≥2 vs. <2 | 1.7 | 0.8, 3.4 | 0.16 |
Number of metastatic sites: >2 vs. ≤2 | 2.6 | 1.4, 4.8 | 0.0023 |
Number of prior therapies: >3 vs. ≤3 | 1.9 | 1.0, 3.5 | 0.042 |
Hemoglobin: <10.5 vs. ≥10.5 g/dL | 4.4 | 2.1, 9.2 | <0.0001 |
Platelets: <200 vs.>200 × 103/L | 2.1 | 1.2, 3.9 | 0.015 |
Lactate dehyrdogenas (LDH): ≤618 [normal] vs. >618 U/L [>ULN] | 2.2 | 1.1, 4.2 | 0.018 |
Creatinine: <1.3 vs. ≥1.3 mg/dL | 0.4 | 0.1, 0.9 | 0.024 |
Note: Age, ECOG PS, Bilirubin, and Albumin were removed from the model due to p > 0.50. Adding Prior Radiation to the above model gives HR = 0.5 (0.3, 1.0) with p = 0.070.