Table 3. Androgen receptor mutants expressed in CR-PCa tumors and cell lines.

Mutation	Aberrant Effect	Cell Line Expression	References
T878A	Activated by DHEAa, estradiol, progesterone, cyproterone acetate, flutamide, nilutamide	LNCaP, C4-2, MDA-PCa2a/b	[99, 101–108]
H875Y/T	Activated by DHEA, estradiol, progesterone, flutamide, nilutamide	22Rv1, CWR-R1	[99, 101–102]
W742C	Activated by bicalutamide	Long-term treatment of LNCaP with bicalutamide	[109]
L702H	Activated by glucocorticoids	MDA-PCa2a/b	[102, 104, 111–112]
F877L	Activated by enzalutamide, ARN-509	Long-term treatment of LNCaP with enzalutamide, ARN-509	[154]

^aDHEA: Dehydroepiandrosterone