Table 1. The enzymatic activity of TET family proteins in neural development.
| TET proteins | Role in neural development | Intervention method | Ref |
|---|---|---|---|
| TET1 | OL development | siRNA | [67] |
| neurogenesis | shRNA | [27] | |
| adult hippocampal neurogenesis and cognition | KO | [65] | |
| TET2 | OL development | siRNA | [67] |
| neurogenesis | shRNA | [27] | |
| TET3 | mOSN development | overexpression | [64] |
| OL development | siRNA | [67] | |
| neurogenesis | shRNA | [27] | |
| Xenopus eye and neural development | cKO | [66] |
Note: OL: Oligodendrocyte; mOSN: mature olfactory sensory neuron; shRNA: short hairpin RNA; siRNA: small interfering RNA; KO: Knockout; cKO: conditional knockout