Table 2. Epigenetic marks located at rs12722489 and rs706779 according to the Roadmap Epigenomics Consortium data [25].
Sample | H3K4me1 | H3K27ac | |||
---|---|---|---|---|---|
rs12722489 | rs706779 | rs12722489 | rs706779 | ||
T cells with high IL2RA expression | CD4+ CD25- IL17+ PMA-Ionomycin stimulated Th17 | + | ++ | +++ | ++ |
CD4+ CD25+ CD127- Treg Primary Cells | + | + | ++ | ++ | |
Other T cells | CD4+ CD25- CD45RA+ Naive Primary Cells | + | |||
CD4+ Naive Primary Cells | + | ||||
CD4+ CD25int CD127+ Tmem Primary Cells | + | + | |||
CD4+ Memory Primary cells | + | + | |||
CD4+ CD25- CD45RO+ Memory Primary Cells | + | + | |||
CD8+ Naive Primary Cells | |||||
CD8+ Memory Primary Cells | |||||
Other leukocytes | CD19+ Primary Cells | ++ | +++ | ||
CD56+ Primary Cells | + | + | + | ||
CD14+ Primary Cells | |||||
Other tissues* | Neurospheres, Ganglionic Eminence Derived | + | |||
Fetal Adrenal Gland | + |
Histone 3 lysine 4 monomethylation (H3K4me1) is associated with enhancer regions, histone 3 lysine 27 acetylation (H3K27ac) is associated with increased activation of enhancer and promoter regions [25].
(+), (++), (+++) designate relative peak height in arbitrary units.