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. 2017 Feb 24;12(2):e0172681. doi: 10.1371/journal.pone.0172681

Table 2. Epigenetic marks located at rs12722489 and rs706779 according to the Roadmap Epigenomics Consortium data [25].

Sample H3K4me1 H3K27ac
rs12722489 rs706779 rs12722489 rs706779
T cells with high IL2RA expression CD4+ CD25- IL17+ PMA-Ionomycin stimulated Th17 + ++ +++ ++
CD4+ CD25+ CD127- Treg Primary Cells + + ++ ++
Other T cells CD4+ CD25- CD45RA+ Naive Primary Cells +
CD4+ Naive Primary Cells +
CD4+ CD25int CD127+ Tmem Primary Cells + +
CD4+ Memory Primary cells + +
CD4+ CD25- CD45RO+ Memory Primary Cells + +
CD8+ Naive Primary Cells
CD8+ Memory Primary Cells
Other leukocytes CD19+ Primary Cells ++ +++
CD56+ Primary Cells + + +
CD14+ Primary Cells
Other tissues* Neurospheres, Ganglionic Eminence Derived +
Fetal Adrenal Gland +

Histone 3 lysine 4 monomethylation (H3K4me1) is associated with enhancer regions, histone 3 lysine 27 acetylation (H3K27ac) is associated with increased activation of enhancer and promoter regions [25].

(+), (++), (+++) designate relative peak height in arbitrary units.