Table 2. Biological processes enriched among OTS167 upregulated genes.
| GO Bioprocess | Genes | p-value |
|---|---|---|
| MDA-MB-231/SUM-159 | ||
| Mitosis | 11/8 | 2.71E-05/ 1.29E-05 |
| Cellular response to DNA damage stimulus | 10/6 | 1.79E-03/ 4.05E-03 |
| Cell Cycle | 13/13 | 2.00E-03/ 5.47E-07 |
| Cell Division | 8/8 | 9.00E-03/ 5.56E-05 |
| DNA repair | 8/8 | 9.87E-03/ 6.24E-05 |
| Apoptotic process | 13/7 | 1.60E-02/ 3.27E-02 |
| Chromatin modification | 6/4 | 2.15E-02/ 1.73E-02 |
| MDA-MB-231 Only | ||
| Transcription, DNA-templated | 40 | 5.88E-06 |
| Neg. regulation of cell-matrix adhesion | 4 | 6.31E-06 |
| Neg. regulation of transcription from RNA poly II promoter | 4 | 4.77E-04 |
| Neg. regulation of transcription, DNA-templated | 13 | 4.96E-04 |
| Positive regulation of protein ubiquination | 4 | 9.35E-04 |
| Positive regulation of calcium ion import | 2 | 3.37E-03 |
| Phosphorylation | 13 | 4.25E-03 |
| Regulation of cell differentiation | 5 | 7.60E-03 |
| DNA recombination | 4 | 1.06E-02 |
| SUM-159 Only | ||
| Nucleosome assembly | 9 | 6.41E-09 |
| G1-S transition of mitotic cell cycle | 7 | 3.03E-06 |
| DNA replication | 6 | 5.28E-05 |
| Telomere maintenance via recombination | 3 | 1.19E-04 |
| Nuclear migration | 2 | 3.73E-04 |
| Cytokine-mediated signaling pathway | 5 | 2.42E-03 |
| mRNA processing | 5 | 8.12E-03 |
| RNA splicing | 4 | 2.82E-02 |
| Intracellular signal transduction | 5 | 3.63E-02 |
Gene lists of differentially expressed genes from MDA-MB-231 and SUM-159 after 72h treatment (45nM) were analyzed separately. Corresponding biological processes, as classified by Gene Ontology, that were significantly enriched in both cell lines are listed at the top; along with number of genes regulated in each cell lines and corresponding p-value, respectively. Processes enriched in only one of the cell line listed below.