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. 2017 Feb 24;12(2):e0173076. doi: 10.1371/journal.pone.0173076

Fig 4. Impact of maternal high-fat diet intake on offspring HFD-induced insulin resistance.

Fig 4

Maternal low-fat diet (mLFD) or maternal high-fat diet (mHFD) offspring were fed a LFD after weaning throughout an age of 15 wks. Afterwards they received a HFD for 10 wks. Half of each group had access to a running wheel (RW) for voluntary training. (A) glucose tolerance, (B) insulin sensitivity, (C) pancreas insulin content and (D) basal blood glucose concentration. The dotted line in C/D indicates the level of the Con group (mLFD-RW LFD). Data are mean ±SE (A) n = 8-15; (B) n = 10-15; (C) n = 5-6; (D) n = 6-12. Data were compared by two-way ANOVA (Bonferroni post hoc test). # indicates significant differences between the maternal diets (mLFD and mHFD), whereas * indicates significant RW effects (-RW vs. +RW).