Figure 4. Mediation analysis between hippocampal activation, longitudinal amyloid accumulation, and memory decline.
Mediation analysis with hippocampal activation at baseline (predictor, X), mediated by [11C] Pittsburgh Compound-B distribution volume ratio slopes (PIB Slope) (mediator, M), predicting California Verbal Learning Test Long-Delay Free Recall slope (CVLT Slope). Hippocampal activation positively predicted PIB Slope, PIB Slope negatively predicted CVLT Slope, which resulted in a significant mediation (see text for more details).