Table 1.

	Human Studies
	Bone Mass	BM fat	Body Fat	Fracture Risk
Observational studies
Growth	↑	↑	↑	—
Aging	↓	↑	↑	↑
Osteoporosis	↓	↑	—	↑
Anorexia nervosa	↓	↑	↓	↑
Obesity	↑	↑	↑
Diabetes	↑	↑	↑	↑
HIV	↓	↓	↓	↑
Lipodystrophy	↓	↓	↓	↑/↓
Interventional studies
TZD	↓	↓	—	↑
Exercise	↑	↓	↓	↓
Estrogen	↑	↓	↓	↓
Bisphosphonate	↑	↓	—	↓
PTH	↑	↓	—	↓
Bariatric surgery	↓	↓/—*	↓
Growth hormone	↑	↑	—	?

^*depending on HbA1c