FIG. 1.

Kidney malformation critical region. Panel A illustrates the chromosome content for everyone with an 18q deletion and kidney malformations using the UCSC Genome Browser Custom Tracks feature. The horizontal light blue bars depict the region of chromosome 18 that is present in two copies. The darker blue sections are the breakpoint regions. All individuals who have retained a distal segment of chromosome 18 have interstitial deletions and not translocations to other chromosomes. Panel B depicts the chromosome content data from the two individuals whose deletions define the smallest common region of hemizygosity. This region is shown along with the known genes in the region.