Table 2.
Regions with R2 alterations in AD dementia†
| Model # | Regions identifier | Principal location (volume, β̄) |
|---|---|---|
| Model 1 | Region 1 | Large portions of WM of all lobes (volume: 57,180 mm3, β̄: −0.265) |
| Model 1 | Region 2 | Insular GM (volume: 1,126 mm3, β̄: 0.287) |
| Model 2 | Region 1 | Large portions of WM of all lobes (volume: 36,172 mm3,β̄: −0.349) |
| Model 2 | Region 2 | Parietal WM (volume: 825 mm3, β̄: −0.295) |
| Model 2 | Region 3 | Insular GM (volume: 202 mm3, β̄: 0.311) |
| Model 3 | Region 1 | Large portions of WM of all lobes (volume: 16,924 mm3, β̄: −0.366) |
| Model 3 | Region 2 | Temporal WM (volume: 1,163 mm3, β̄ : −0.338) |
| Model 3 | Region 3 | Temporal WM (volume: 216 mm3, β̄ : −0.306) |
| Model 3 | Region 4 | Temporal/parahippocampal WM (volume: 243 mm3, β̄ : −0.325) |
| Model 3 | Region 5 | Insular GM (volume: 232 mm3, β̄ : 0.348) |
†
Regions due to artifact of brain atrophy that are sensitive to outliers are not included.
Each region is described in terms of principal location, volume (mm3), and β̄ that represents the difference in standard deviation of R2 values between AD dementia and no cognitive impairment. Model 1 is adjusted only for age and sex; model 2 is adjusted for age, sex and AD pathology; and model 3 is adjusted for age, sex, AD, cerebral infarcts, Lewy bodies, hippocampal sclerosis, and TDP-43 pathologies.
WM: white matter, GM: gray matter