Fig. 3.

Mixed pathologies. a Hippocampal sclerosis (Case 2). b TDP-43-positive neuronal cytoplasmic inclusions in granule cells of the dentate gyrus (arrowheads; Case 2). c Astrocytic plaque in CBD (Case 1, temporal cortex). d Lewy body (Case 4, substantia nigra). e Uniform laminar distribution of Alzheimer-tau pathology which is particularly numerous in the deep cortical layers (red arrows, layer V), which contrasts with the patchy CTE-tau pathology observed in sulcal depths (see Fig. 2); tau-immunoreactive white matter astrocytes (blue arrows) are non-specific features of CTE (Case 3, frontal cortex). f Cerebral amyloid angiopathy of a cortical penetrating vessel (Case 1, frontal cortex). Bar represents 800 µm in (a), 600 µm in (e), 20 µm in (c) and (f), and 10 µm in (b) and (d)