Table 2.

Pathology findings in prefrontal rostral, leucotomy and frontal caudal cortex tissues with subcortical white matter in leucotomized schizophrenia patients and neuroanatomical equivalent sites in non-leucotomized schizophrenia patients

Case number	Prefrontal cortex rostral to leucotomy site	Leucotomy site	Frontal cortex caudal to leucotomy site
Leucotomy
1	Minimal leptomeningeal CAA	Severe white matter astrogliosis, NFTs, p-tau neurites, β-amyloid plaques	One blood vessel with CAA in gray matter
2	Sparse white matter astrogliosis	Severe white matter astrogliosis, NFTs, p-tau neurites, sulcal depths (astrocytic tangles, p-tau cell processes)	–
3	Minimal white matter astrogliosis, scant NFTs and p-tau neurites, one focus subpial p-tau at sulcal depth	Severe white matter astrogliosis, NFTs, p-tau neurites, sulcal depths (astrocytic tangles, p-tau cell processes), β-amyloid plaques	Scant NFTs and p-tau neurites
4	Moderate white matter astrogliosis, scant NFTs and p-tau neurites	Severe white matter astrogliosis, NFTs, p-tau neurites, sulcal depths (astrocytic tangles, p-tau cell processes), β-amyloid plaques	Few β-amyloid plaques
5	Moderate white matter astrogliosis	Severe white matter astrogliosis, NFTs, p-tau neurites, sulcal depths (astrocytic tangles, p-tau cell processes), one focus β-amyloid plaques at sulcal depth	Few β-amyloid plaques
No leucotomy
6	Few β-amyloid plaques	Scant β-amyloid plaques	−
7	−	−	−
8	Scant NFTs	−	−
9	−	−	−
10	Minimal leptomeningeal CAA	Scant NFTs	−

CAA Cerebral amyloid angiopathy, NFTs neurofibrillary tangles, p-tau abnormally hyperphosphorylated tau, − negative findings