Table 1. Effect of tartrazine on serum biochemistry and oxidative biomarkers in male Wistar rats.

Group parameter	Control group	Tartrazine-treated group	p value
Aspartate transaminase (U/ml)	48.40 ± 4.26	128.40 ± 18.97	0.003*
Alanine transaminase (U/ml)	29.40 ± 4.07	71.20 ± 7.75	0.001*
Alkaline phosphatase (U/l)	47.0 ± 5.18	89.40 ± 6.66	0.001*
Creatinine (mg/dl)	0.36 ± 0.07	0.72 ± 0.06	0.004*
Urea (mg/dl)	38.20 ± 1.77	46.0 ± 2.12	0.02*
Uric acid (mg/dl)	0.59 ± 0.07	0.92 ± 0.07	0.009*
Malondialdehyde(nM/ml)	17.33 ± 2.03	46.67 ± 5.61	0.008*
Nitric oxide (µM/l)	16.67 ± 2.85	41.0 ± 3.79	0.007*
Total antioxidants (mM/l)	66.67 ± 4.63	28.33 ± 4.06	0.003*

Notes.

Data represented as mean ± SD.

p: p value for F test (ANOVA) and significant between control and treated groups using Post Hoc Test (LSD).