Figure 2.

Domain diagrams of select SEA‐containing proteins. Domains or regions with sequence motifs are shown as rectangular boxes. N‐terminal signal peptides, transmembrane segments, and EGF domains are shown as yellow, blue and green unlabeled boxes, respectively. Other domains or regions are labeled with their names or name abbreviations in the boxes. The abbreviations are: 7TM – GPCR seven‐pass transmembrane domain; ANK – ankyrin repeats; CA – cadherin domain; Cad_C: cadherin cytoplasmic domain; CADG – cadherin‐like domain in dystroglycan; CU – Cupredoxin domain; D – DUF3454 domain; FG – FG repeat region in nucleoporins; KAZ – Kazal domain; L – LDLa domain; LamG – Laminin G domain; ND – N‐terminal domain of EpCAM; PTPc – protein phosphatase catalytic domain; S/T – serine and threonine rich region; UPAR – UPAR_LY6_2 domain; V – VWC domain. The CADG + SEA module are highlighted with thick red outlines. Names of SEA domains with the autoproteolysis motif are shown in yellow font. Domain diagrams above and below the dashed lines are shown in different length scales (suggested by the arrows) to accommodate several large proteins with more than 3,000 amino acid residues. The majority of these proteins are from human with the exceptions of the sea urchin sperm protein, a Monosiga protein with canonical SEA domains and the DE‐cadherin (shotgun) of D. melanogaster. GenBank accession numbers and protein lengths are shown for each protein.