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. 2017 Feb 14;26(3):436–451. doi: 10.1002/pro.3105

Figure 1.

Figure 1

Protein–ligand interactions by NMR spectroscopy.

A) Representation of a simple two‐state binding process. B.1) General considerations and limitations for NMR sample preparation. B.2) Experiments providing mainly structural information. B.3) Experiments useful for extracting binding information from non‐isotope labelled NMR samples, mainly used for drug discovery. B.4) Information that can be extracted from samples where either the protein or the ligand is labelled with stable isotopes.