Fig. 1.

Prevalance of fatigue overall and by disease. Horizontal black line represents the prevalence of fatigue in the general population. Abbreviations: AGAMMA agammaglobulinemia, CGD chronic granulomatous disease, COMPDEF complement deficiency; CORE diagnosis included autoimmune lymphoproliferative syndrome (ALPS), autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED), ataxia telangiectasia, autoinflammatory syndrome, CD16 deficiency, chronic mucocutaneous candidiasis, Comel-Netherton syndrome, dyskeratosus congenita, GATA2 deficiency, hyper IgE syndrome, IFN-γ receptor-1 deficiency, IL-10 deficiency, immune dysregulation with autoimmunity due to uncertain or unlisted cause, immunodeficiency of unknown cause, immune dysregulation, polyendocrinopathy, enteropathy X-linked (IPEX) IRAK-4 deficiency, hyper IgD syndrome, neutropenia due to uncertain or unlisted cause, other defects in innate immunity, STAT1 deficiency, STAT1 gain-of-function mutations, and UNC13D/Munc13–4 deficiency; CVID common variable immunodeficiency, DGS DiGeorge syndrome, HIGM hyper-IgM syndrome, LAD leukocyte adhesion deficiency, MAD miscellaneous antibody deficiency, NEMO nuclear factor-kappa B essential modulator, SCID severe combined immunodeficiency, WAS Wiskott Aldrich syndrome