Table 2.
Predictors of first biopsy-proven acute rejection based on multivariable Cox regression (A2ALL) and multivariable discrete survival analysis (SRTR)*
| A2ALL (n=890) | SRTR (n=45,423) | |||||
|---|---|---|---|---|---|---|
| Variable | Hazard Ratio |
95% Confidence Interval |
P-value | Hazard Ratio |
95% Confidence Interval |
P-value |
| Biologically related LDLT vs. non-biologically related LDLT and DDLT** |
0.57 | (0.43, 0.76) | <0.001 | 0.78 | (0.66, 0.91) | 0.002 |
| Recipient age, per 10 years, for age < 55 | 0.71 | (0.59, 0.84) | <0.001 | 0.76 | (0.74, 0.79) | <0.001 |
| Recipient age, per 10 years, for age > 55 | 1.12 | (0.77, 1.64) | 0.54 | 0.86 | (0.81, 0.92) | <0.001 |
| Female vs. Male | 1.14 | (0.85, 1.52) | 0.40 | 1.19 | (1.13, 1.25) | <0.001 |
| Race (ref = White) | 0.20 | <0.001 | ||||
| Black | 1.15 | (0.62, 2.15) | 0.65 | 1.26 | (1.16, 1.35) | <0.001 |
| Asian | 1.91 | (1.05, 3.47) | 0.03 | 0.87 | (0.77, 0.98) | 0.03 |
| Other races | 1.03 | (0.57, 1.86) | 0.93 | 0.95 | (0.76, 1.19) | 0.67 |
| Recipient diagnosis: HCV | 2.22 | (1.57, 3.16) | <0.001 | 1.11 | (1.05, 1.18) | <0.001 |
| Recipient diagnosis: Autoimmune hepatitis | 1.16 | (0.66, 2.06) | 0.60 | 0.99 | (0.88, 1.12) | 0.87 |
| Recipient diagnosis: PSC | 1.08 | (0.71, 1.65) | 0.72 | 1.32 | (1.20, 1.45) | <0.001 |
| Recipient diagnosis: PBC | 2.10 | (1.31, 3.36) | 0.002 | 1.37 | (1.22, 1.53) | <0.001 |
| MELD at transplant (per 5 points) | - | - | - | 0.99 | (0.98, 1.00) | 0.17 |
*
Model included adjustments for induction immunosuppression and immunosuppression at discharge from transplant hospitalization, presented in Supplemental Table 4
**
No significant difference between non-biologically related LDLT and DDLT (p=0.71 in A2ALL, p=0.57 in SRTR).
LDLT = living donor liver transplant, DDLT = deceased donor liver transplant, HCV = hepatitis C virus, PSC = primary sclerosing cholangitis, PBC = primary biliary cirrhosis,, MELD = model for end stage liver disease.