Table 3.

Predictors of patient death and graft failure based on multivariable Cox regression in A2ALL and SRTR^*

	Patient Death						Graft Failure
	A2ALL (n=890)			SRTR (n=45,423)			A2ALL (n=890)			SRTR (n=45,423)
Variable	Hazard Ratio	95% Confidence Interval	p-value	Hazard Ratio	95% Confidence Interval	p-value	Hazard Ratio	95% Confidence Interval	p-value	Hazard Ratio	95% Confidence Interval	p-value
Biopsy-proven rejection within 6 months post-LT
< 12 months following rejection	1.86	(1.00, 3.47)	0.05	1.66	(1.52, 1.83)	<0.001	1.91	(1.21, 3.01)	0.01	1.77	(1.63, 1.92)	<0.001
> 12 months following rejection	1.23	(0.63, 2.41)	0.54	1.24	(1.13, 1.36)	<0.001	1.11	(0.60, 2.05)	0.74	1.32	(1.21, 1.43)	<0.001
Biopsy-proven rejection 6–12 months post-LT
< 12 months following rejection	2.02	(0.27, 15.24)	0.49	2.99	(2.14, 4.18)	<0.001	1.57	(0.21, 11.63)	0.66	3.35	(2.54, 4.40)	<0.001
> 12 months following rejection	1.29	(0.17, 9.66)	0.80	1.53	(1.28, 1.83)	<0.001	0.96	(0.13, 7.04)	0.96	1.62	(1.37, 1.91)	<0.001
Biopsy-proven rejection > 12 months post-LT
< 12 months following rejection	8.81	(3.37, 23.04)	<0.001	3.94	(3.22, 4.83)	<0.001	6.79	(2.64, 17.45)	<0.001	4.41	(3.71, 5.23)	<0.001
> 12 months following rejection	4.38	(1.49, 12.92)	0.01	1.64	(1.31, 2.04)	<0.001	3.35	(1.16, 9.73)	0.03	1.70	(1.39, 2.08)	<0.001
Medical severity at transplant (recipient on ventilator or dialysis)	3.32	(1.51, 7.28)	0.003	1.69	(1.58, 1.82)	<0.001	2.95	(1.54, 5.64)	0.001	1.60	(1.50, 1.71)	<0.001
Recipient age, per 10 years, < 55	1.18	(0.83, 1.67)	0.35	1.13	(1.09, 1.17)	<0.001	0.97	(0.77, 1.22)	0.78	1.02	(0.99, 1.05)	0.31
Recipient age, per 10 years, > 55	2.52	(1.66, 3.83)	<0.001	1.45	(1.38, 1.52)	<0.001	1.83	(1.29, 2.60)	0.001	1.31	(1.25, 1.37)	<0.001
Donor age, per 10 years	1.20	(1.04, 1.38)	0.01	1.11	(1.10, 1.13)	<0.001	1.23	(1.10, 1.38)	<0.001	1.13	(1.12, 1.14)	<0.001
Recipient diagnosis: HCV	1.13	(0.73, 1.76)	0.57	1.45	(1.38, 1.51)	<0.001	1.17	(0.83, 1.66)	0.37	1.40	(1.34, 1.46)	<0.001
Recipient diagnosis: Autoimmune hepatitis	0.28	(0.07, 1.18)	0.08	0.99	(0.88, 1.12)	0.91	0.28	(0.09, 0.88)	0.03	1.01	(0.91, 1.12)	0.85
Recipient diagnosis: PSC	0.60	(0.30, 1.18)	0.14	0.69	(0.62, 0.78)	<0.001	0.74	(0.46, 1.19)	0.21	0.84	(0.76, 0.92)	<0.001
Recipient diagnosis: PBC	1.04	(0.52, 2.10)	0.90	0.76	(0.67, 0.86)	<0.001	0.76	(0.41, 1.42)	0.39	0.83	(0.75, 0.93)	0.001
MELD at transplant, per 5 points	.			1.04	(1.03, 1.05)	<0.001	.			1.02	(1.01, 1.04)	<0.001

^*In SRTR, time of rejection was randomly assigned in the interval in which rejection was reported to occur.