Table 4.

Risk of Death due to Graft Failure and Non-Graft Failure Causes (SRTR Only)

	Death due to graft failure			Death due to leading non- graft failure causes*
	HR	95% CI	p-value	HR	95% CI	p-value
Biopsy-proven rejection (time-dependent) in the first 6 months post-transplant
< 12 months post-rejection	3.04	(2.45, 3.77)	<0.001	1.48	(1.28, 1.72)	<0.001
> 12 months post-rejection	2.06	(1.66, 2.56)	<0.001	1.08	(0.93, 1.24)	0.31
Biopsy-proven rejection (time-dependent) 6–12 months post-transplant
< 12 months post-rejection	5.14	(3.25, 8.12)	<0.001	2.49	(1.67, 3.73)	<0.001
> 12 months post-rejection	2.41	(1.44, 4.03)	0.001	1.57	(1.17, 2.11)	0.003
Biopsy-proven rejection (time-dependent) > 12 months post-transplant
< 12 months post-rejection	12.02	(8.54, 16.93)	<0.001	2.37	(1.62, 3.47)	<0.001
> 12 months post-rejection	2.84	(1.37, 5.89)	0.01	1.53	(1.10, 2.12)	0.01
Medical severity at transplant (recipient on ventilator or dialysis)	1.14	(0.93, 1.40)	0.21	1.99	(1.79, 2.22)	<0.001
Recipient age, per 10 years, < 55	0.88	(0.80, 0.96)	0.005	1.28	(1.21, 1.36)	<0.001
Recipient age, per 10 years, > 55	1.00	(0.85, 1.16)	0.97	1.56	(1.46, 1.68)	<0.001
Donor age, per 10 years	1.24	(1.20, 1.28)	<0.001	1.09	(1.07, 1.11)	<0.001
MELD at transplant, per 5 points	1.09	(1.05, 1.12)	<0.001	1.01	(0.99, 1.03)	0.31
Recipient diagnosis: Autoimmune hepatitis	0.92	(0.63, 1.35)	0.67	1.03	(0.87, 1.23)	0.71
Recipient diagnosis: PSC	0.54	(0.36, 0.80)	0.002	0.79	(0.67, 0.94)	0.01
Recipient diagnosis: PBC	0.82	(0.55, 1.23)	0.35	0.71	(0.59, 0.85)	<0.001
Recipient diagnosis: HCV	3.14	(2.75, 3.59)	<0.001	1.20	(1.12, 1.28)	<0.001

^*Cardiovascular, renal, infection, malignancy