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. 2016 Oct 14;8(3):202–218. doi: 10.1007/s13238-016-0324-z

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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UHRF2 regulates the expression and activity of TIP60. (A, C and E) HEK293, LO2 and HepG2 cells were transfected with control or Flag-UHRF2 plasmids. They were exposed to MG132 (10 μg/mL) for 12 h and harvested. The cellular lysates were analyzed by Western blot. (B, D and F) HEK293, LO2 and HepG2 cells were transfected with shNC or shUHRF2. After 48 h, the total cellular lysates were analyzed by Western blot. Data were expressed as means ± SD, n = 3. Significance was indicated as *P < 0.05, and non-significance as n.s P > 0.05. (G–I) HEK293, LO2 and HepG2 cells were transfected with the plasmids as shown. The cellular lysates were analyzed by Western blot. (J and K) Immunofluorescence analyses were performed using anti-TIP60 or anti-HDAC1 antibodies

UHRF2 regulates the expression and activity of TIP60. (A, C and E) HEK293, LO2 and HepG2 cells were transfected with control or Flag-UHRF2 plasmids. They were exposed to MG132 (10 μg/mL) for 12 h and harvested. The cellular lysates were analyzed by Western blot. (B, D and F) HEK293, LO2 and HepG2 cells were transfected with shNC or shUHRF2. After 48 h, the total cellular lysates were analyzed by Western blot. Data were expressed as means ± SD, n = 3. Significance was indicated as *P < 0.05, and non-significance as n.s P > 0.05. (G–I) HEK293, LO2 and HepG2 cells were transfected with the plasmids as shown. The cellular lysates were analyzed by Western blot. (J and K) Immunofluorescence analyses were performed using anti-TIP60 or anti-HDAC1 antibodies