Table 3. Genotype and allele frequencies of CTLA4 (+49 A>G and chr2:203868145 A>C) in patients with T1D and controls .
Genes | SNP types | Patients (%) | Controls (%) | Odd ratio (95% CI) | P value |
CTLA4 | +49 A>G | ||||
AA | 36 (72) | 41 (82) | 1.00 | 0.24 | |
AG | 2 (4) | 7 (14) | 1.00 | 0.08 | |
GG | 12 (24) | 2 (4) | 2.17 (0.67-6.96) | 0.004* | |
A | 74 (74) | 89 (89) | 1.2 (0.19-8.72) | 0.006* | |
G | 26 (26) | 11 (11) | 1.03 (0.26-1.93) | 0.006* | |
chr2:203868145 | |||||
AA | 39 (78) | 47 (94) | 1.00 | 0.02* | |
AC | 8 (16) | 3 (6) | 1.00 | 0.11 | |
CC | 3 (6) | 0 (0) | 0.00 | 0.08* | |
A | 86 (86) | 97 (97) | 2.03 (0.61-6.46) | 0.005* | |
C | 14 (14) | 3 (3) | 1.22 (0.06-8.47) | 0.005* |
Chr2: chromosome 2, SNP: single nucleotide polymorphism.