Table 1.
Long-term outcomes after LT for NASH.
| Author, year | Country, Period | Population, sample size | Mean MELD score |
Patient survival, % | Leading cause of death | ||
|---|---|---|---|---|---|---|---|
| 1 yr | 3 yr | 5 yr | |||||
| Malik, 2009 | US single center 1997–2008 |
NASH = 98 | 17 | 79% | 74% | 72% | Infections: 57% CV: 21% |
| Yalamanchili, 2010 | US single center 1986–2004 |
NASH = 18, CC = 239 | - | 85% | - | 71%* | CV: 21% Malignancies: 18% Infections: 15% |
| Bhagat, 2009 | US single center 1997–2007 |
NASH = 71 | - | 82% | 79% | 75% | Infections: 53% CV: 26% |
| Barritt, 2011 | US single center 2004–2007 |
NASH = 21 | 23 | 76% | 76% | - | Infections: 20% CV: 20% |
| Houlihan, 2011 | Israel, single center 2000–2008 |
NASH = 48 | 15 | 88% | - | 82% | CV events, sepsis |
| Park, 2011 | US single center 1998–2008 |
NASH = 9 | 13 | 78% | - | - | n.r. |
| Charlton, 2011 | US, SRTR registry 2001–2009 |
NASH = 1840 | - | 84% | 78% | No accurate information on causes of death or graft loss |
|
| Agopian 2012 | US single center 2002–2011 |
NASH = 144 | 33 | 84% | 75% | 70% | n.r. |
| Reddy, 2012 | US single center 2000–2010 |
NASH-HCC (LT) = 20 | 9 | - | 83% | - | Liver failure. Similar overall survival in patients with NASH and HCV/ ALD-related HCC |
| Van Wagner 2012 | US single center 1993–2010 |
NASH = 115 | 24 | 81% | 73% | 60% | Infections: 11% CV events: 9% |
| Kennedy 2012 | US single center 1999–2009 |
NASH = 129 | 23 | 90% | 88% | 85% | Infections: 38% CV events: 19% |
| Afzali 2012* | US, UNOS data- base 1997–2010 |
NASH = 1810; CC = 3843. | 21 | 87% | 81% | 75%* | Primary cause of death missing or unknown in 25% of the cases. CV events: 19% |
*
NASH and CC combined.
ALD, alcoholic liver disease; CC, cryptogenic cirrhosis; CV, cardiovascular; HBV, hepatitis B; HCV, hepatitis C; NASH, non-alcoholic steatohepatitis; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; UNOS, United Network for organ sharing; SRTR, Scientific Registry for Transplant Recipients.